Recommendations for the Management of Post Tuberculosis Lung Disease Departamento de Tuberculosis ALAT
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Abstract
Introduction: Efforts to combat tuberculosis (TB) usually focus on early, rapid diagnosis and effective treatment to break the chain of transmission of Mycobacterium Tuberculosis. However, in the last few years, coinciding with the syndemic TB/COVID-19 association, more and more evidence has proved the serious clinical, functional and psychosocial sequelae that TB can cause. This condition has been defined as Post-Pulmonary Disease Tuberculosis (PTLD) and it affects approximately one-third of the patients who survive TB, facing persistent respiratory symptoms with episodic exacerbations, chronic respiratory failure, emotional disorders and psychosocial challenges that negatively impact their life quality, meaning a high catastrophic cost.
Objective: Provide a shared, guiding and scientifically valid model to promptly diagnose, evaluate and treat patients with PTLD (prevention, diagnosis, treatment and possible rehabilitation).
Methodology: It is documentary research that includes systematic reviews, meta-analysis, observational studies and the guidelines that have existed in recent years in this regard, added to an evaluation by experts, with the purpose of adapting them to local conditions of each Latin American country.
Conclusions: Considering the global and, particularly, the Latin American burden of TB, and the estimated burden of PTLD, the development of a consensus document on this topic is urgent. Therefore, we think ALAT recommendations will provide the basis for the formulation and adoption of national specific guidelines for the management of PTLD in Latin America.
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References
Allwood BW, van der Zalm MM, Amaral AFS et al. Post-tuberculosis lung health: perspectives from the First International Symposium. Int J Tuberc Lung Dis 2020; 24(8):820-828. Doi: 10.5588/ijtld.20.0067.
Van Kampen SC, Wanner A, Edwards M et al. International research and guidelines on post-tuberculosis chronic lung disorders: a systematic scoping review. BMJ Glob Health 2018; 3(4):e000745.
Tomeny EM, Nightingale R, Chinoko B et al. TB morbidity estimates overlook the contribution of post-TB disability: evidence from urban Malawi. BMJ Glob Health 2022;7(5):e007643. Doi: 10.1136/bmjgh-2021-007643.
Nightingale R, Carlin F, Meghji J et al. Post-TB health and wellbeing. Int J Tuberc Lung Dis 2023;27(4):248-283. Doi: 10.5588/ijtld.22.0514.
Romanowski K, Baumann B, Basham CA, Ahmad Khan F, Fox GJ, Johnston JC. Long-term all-cause mortality in people treated for tuberculosis: a systematic review and meta-analysis. Lancet Infect Dis 2019;19(10):1129-1137. Doi: 10.1016/S1473-3099(19)30309-3.
Ranzani OT, Rodrigues LC, Bombarda S, Minto CM, Waldman EA, Carvalho CRR. Long-term survival and cause-specific mortality of patients newly diagnosed with tuberculosis in São Paulo state, Brazil, 2010-15: a population-based, longitudinal study. Lancet Infect Dis 2020;20(1):123-132. Doi: 10.1016/S1473-3099(19)30518-3.
Allwood BW, Byrne A, Meghji J, Rachow A, van der Zalm MM, Schoch OD. Post-Tuberculosis Lung Disease: Clinical Review of an Under-Recognised Global Challenge. Respiration 2021;100(8):751-763. Doi: 10.1159/000512531.
Visca D, Ambrosio L, Centis R, Pontali E, Tiberi S, Migliori GB. Post-TB disease: a new topic for investigation-and why it matters. Int J Tuberc Lung Dis 2021;25(4):258-261. Doi: 10.5588/ijtld.21.0040.
Dodd PJ, Yuen CM, Jayasooriya SM, van der Zalm MM, Seddon JA. Quantifying the global number of tuberculosis survivors: a modelling study. Lancet Infect Dis 2021;21(7):984-992. Doi: 10.1016/S1473-3099(20)30919-1.
Pasipanodya JG, McNabb SJ, Hilsenrath P et al. Pulmonary impairment after tuberculosis and its contribution to TB burden. BMC Public Health 2010; 10:259. Doi: 10.1186/1471-2458-10-259.
Amaral AF, Coton S, Kato B et al. Tuberculosis associates with both airflow obstruction and low lung function: BOLD results. Eur Respir J 2015; 46(4):1104-12. Doi: 10.1183/13993003.02325-2014.
Allwood BW, Stolbrink M, Baines N et al. Persistent chronic respiratory symptoms despite TB cure is poorly correlated with lung function. Int J Tuberc Lung Dis 2021; 25(4):262-270. Doi: 10.5588/ijtld.20.0906.
Menzies NA, Quaife M, Allwood BW et al. Lifetime burden of disease due to incident tuberculosis: a global reappraisal including post-tuberculosis sequelae. Lancet Glob Health 2021; 9(12):e1679-e1687. Doi: 10.1016/S2214-109X (21)00367-3.
Pontali E, Silva DR, Marx FM et al. Breathing Back Better. A State of the Art on the Benefits of Functional Evaluation and Rehabilitation of Post-Tuberculosis and Post-COVID Lungs. Arch Bronconeumol 2022; 58(11):754-763. Doi: 10.1016/j.arbres.2022.05.010.
Martinez-Garcia MA, Guan WJ, de-la-Rosa D et al. Post-TB bronchiectasis: from pathogenesis to rehabilitation. Int J Tuberc Lung Dis 2023; 27(3):175-181. Doi: 10.5588/ijtld.22.0566.
Hsu D, Irfan M, Jabeen K et al. Post tuberculosis treatment infectious complications. Int J Infect Dis 2020; 92S:S41-S45. Doi: 10.1016/j.ijid.2020.02.032.
Pasipanodya JG, Miller TL, Vecino M et al Pulmonary impairment after tuberculosis. Chest 2007; 131(6):1817-24. Doi: 10.1378/chest.06-2949
Tiberi S, Torrico MM, Rahman A et al. Managing severe tuberculosis and its sequelae: from intensive care to surgery and rehabilitation. J Bras Pneumol 2019; 45(2): e20180324. Doi: 10.1590/1806-3713/e20180324.
Migliori GB, Caminero Luna J, Kurhasani X et al. History of prevention, diagnosis, treatment and rehabilitation of pulmonary sequelae of tuberculosis. Presse Med 2022; 51(3):104112. Doi: 10.1016/j.lpm.2022.104112.
Mpagama SG, Msaji KS, Kaswaga O et al. The burden and determinants of post-TB lung disease. Int J Tuberc Lung Dis 2021; 25(10):846-853. Doi: 10.5588/ijtld.21.0278.
Miller TL, Wilson FA, Pang JW et al. Mortality hazard and survival after tuberculosis treatment. Am J Public Health 2015; 105(5):930-7. Doi: 10.2105/AJPH.2014.302431.
Ravimohan S, Kornfeld H, Weissman D, Bisson GP. Tuberculosis and lung damage: from epidemiology to pathophysiology. Eur Respir Rev 2018; 27(147):170077. Doi: 10.1183/16000617.0077-2017.
Silva DR, Freitas AA, Guimarães AR et al. Post-tuberculosis lung disease: a comparison of Brazilian, Italian, and Mexican cohorts. J Bras Pneumol 2022; 48(2):e20210515. Doi: 10.36416/1806-3756/e20210515.
Meghji J, Simpson H, Squire SB, Mortimer K. A Systematic Review of the Prevalence and Pattern of Imaging Defined Post-TB Lung Disease. PLoS One 2016; 11(8):e0161176. Doi: 10.1371/journal.pone.0161176.
Maleche-Obimbo E, Odhiambo MA, Njeri L et al. Magnitude and factors associated with post-tuberculosis lung disease in low- and middle-income countries: A systematic review and meta-analysis. PLOS Glob Public Health 2022; 2(12):e0000805. Doi: 10.1371/journal.pgph.0000805.
Migliori GB, Marx FM, Ambrosino N et al. Clinical standards for the assessment, management and rehabilitation of post-TB lung disease. Int J Tuberc Lung Dis 2021; 25(10):797-813. Doi: 10.5588/ijtld.21.0425.
Chesov D, Butov D, Reimann M et al. Impact of lung function on treatment outcome in patients with TB. Int J Tuberc Lung Dis 2021; 25(4):277-284. Doi: 10.5588/ijtld.20.0949.
Muñoz-Torrico M, Rendon A, Centis R et al. Is there a rationale for pulmonary rehabilitation following successful chemotherapy for tuberculosis? J Bras Pneumol 2016; 42(5):374-385. Doi: 10.1590/S1806-37562016000000226.
Tiberi S, Torrico MM, Rahman A et al. Managing severe tuberculosis and its sequelae: from intensive care to surgery and rehabilitation. J Bras Pneumol 2019; 45(2): e20180324. Doi: 10.1590/1806-3713/e2018032.
Muñoz-Torrico M, Cid-Juárez S, Gochicoa-Rangel L et al. Functional impact of sequelae in drug-susceptible and multidrug-resistant tuberculosis. Int J Tuberc Lung Dis 2020; 24(7):700-705. Doi: 10.5588/ijtld.19.0809.
Ross J, Ehrlich RI, Hnizdo E, White N, Churchyard GJ. Excess lung function decline in gold miners following pulmonary tuberculosis. Thorax 2010; 65(11):1010-5. Doi: 10.1136/thx.2009.129999.
Bongomin F. Post-tuberculosis chronic pulmonary aspergillosis: An emerging public health concern. PLoS Pathog 2020; 16(8):e1008742. Doi: 10.1371/journal.ppat.1008742.
Nightingale R, Chinoko B, Lesosky M et al. Respiratory symptoms and lung function in patients treated for pulmonary tuberculosis in Malawi: a prospective cohort study. Thorax 2022; 77(11):1131-1139. Doi: 10.1136/thoraxjnl-2021-217190.
Marx FM, Floyd S, Ayles H, Godfrey-Faussett P, Beyers N, Cohen T. High burden of prevalent tuberculosis among previously treated people in Southern Africa suggests potential for targeted control interventions. Eur Respir J 2016; 48(4):1227-1230. Doi: 10.1183/13993003.00716-2016.
Singh S, Allwood BW, Chiyaka TL et al. Immunologic and imaging signatures in post tuberculosis lung disease. Tuberculosis (Edinb) 2022; 136:102244. Doi: 10.1016/j.tube.2022.102244.
Gupta MB, Bagri S, Garg A, Singh DK, Choudhary P, Sahni S. Pulmonary function in cured pulmonary tuberculosis cases. Indian J Tuberc 2022; 69(4):535-538. Doi: 10.1016/j.ijtb.2021.08.024.
Curry BD, Wout E van T, Maasdorp E et al. Correlation between lung function tests and peak oxygen consumption in post-TB lung disease. Int J Tuberc Lung Dis 2022; 26(3):259-267. Doi: 10.5588/ijtld.21.0504.
Sivaranjini S, Vanamail P, Eason J. Six minute walk test in people with tuberculosis sequelae. Cardiopulm Phys Ther J 2010; 21(3):5-10.
Pereira MC, Athanazio RA, Dalcin PTR et al. Brazilian consensus on non-cystic fibrosis bronchiectasis. J Bras Pneumol 2019; 45(4):e20190122. Doi: 10.1590/1806-3713/e20190122.
American Thoracic Society; American College of Chest Physicians. ATS/ACCP Statement on cardiopulmonary exercise testing. Am J Respir Crit Care Med 2003; ;167(2):211-77. Doi: 10.1164/rccm.167.2.211.
Venkitakrishnan R, Ramachandran D, Augustine J, Cleetus M. Inhaled corticosteroids and risk of tuberculosis-How bad is the risk? Indian J Tuberc 2022; 69(2):128-130. Doi: 10.1016/j.ijtb.2021.06.010.
Martínez-García MÁ, Oscullo G, García-Ortega A, Matera MG, Rogliani P, Cazzola M. Inhaled Corticosteroids in Adults with Non-cystic Fibrosis Bronchiectasis: From Bench to Bedside. A Narrative Review. Drugs 2022; 82(14):1453-1468. Doi: 10.1007/s40265-022-01785-1.
Bongomin F, Harris C, Hayes G, Kosmidis C, Denning DW. Twelve-month clinical outcomes of 206 patients with chronic pulmonary aspergillosis. PLoS ONE 2018; 13:e0193732. Doi: 10.1371/journal.pone.
Pellegrino R, Viegi G, Brusasco V et al. Interpretative strategies for lung function tests. Eur Respir J 2005; 26(5):948-68. Doi: 10.1183/09031936.05.00035205.
Crapo RO, Jensen RL, Hegewald M, Tashkin DP. Arterial blood gas reference values for sea level and an altitude of 1,400 meters. Am J Respir Crit Care Med 1999; 160(5 Pt 1):1525-31. Doi: 10.1164/ajrccm.160.5.9806006
Holland AE, Spruit MA, Troosters T et al. An official European Respiratory Society/American Thoracic Society technical standard: field walking tests in chronic respiratory disease. Eur Respir J 2014 ;44(6):1428–46. Doi: 10.1183/09031936.00150314.
Jones SE, Kon SS, Canavan JL et al. The five-repetition sit-to-stand test as a functional outcome measure in COPD. Thorax 2013; 68(11):1015-20. Doi: 10.1136/thoraxjnl-2013-203576.
Grønseth R, Vollmer WM, Hardie JA et al. Predictors of dyspnoea prevalence: results from the BOLD study. Eur Respir J 2014; 43(6):1610-20. Doi: 10.1183/09031936.00036813.
Bestall JC, Paul EA, Garrod R, Garnham R, Jones PW, Wedzicha JA. Usefulness of the Medical Research Council (MRC) dyspnoea scale as a measure of disability in patients with chronic obstructive pulmonary disease. Thorax 1999; 54(7):581-6. Doi: 10.1136/thx.54.7.581.
Borg GA. Psychophysical bases of perceived exertion. Med Sci Sports Exerc 1982;14(5):377-81.
Gift AG. Validation of a vertical visual analogue scale as a measure of clinical dyspnea. Rehabil Nurs 1989; 14(6):323-5. Doi: 10.1002/j.2048-7940. 1989.tb01129.x.
Sancho J, Servera E, Díaz J, Marín J. Comparison of peak cough flows measured by pneumotachograph and a portable peak flow meter. Am J Phys Med Rehabil 2004; 83(8):608-12. Doi: 10.1097/01.phm.0000133431. 70907.a2.
American Thoracic Society/European Respiratory Society. ATS/ERS Statement on respiratory muscle testing. Am J Respir Crit Care Med 2002; 166(4):518-624. Doi: 10.1164/rccm.166.4.518.
Kim SJ, Lee J, Park YS et al. Effect of airflow limitation on acute exacerbations in patients with destroyed lungs by tuberculosis. J Korean Med Sci 2015; 30(6):737-42. Doi: 10.3346/jkms.2015.30.6.737.
2023 GOLD Report - Global Initiative for Chronic Obstructive Lung Disease - GOLD. [Internet]. [Consultado 29 May 2023]. Disponible en: https://goldcopd.org/2023-gold-report-2/
Linn BS, Linn MW, Gurel L. Cumulative illness rating scale. J Am Geriatr Soc 1968; 16(5):622-6. Doi: 10.1111/j.1532-5415. 1968.tb02103.x.
Datta S, Gilman RH, Montoya R et al. Quality of life, tuberculosis and treatment outcome; a case-control and nested cohort study. Eur Respir J 2020; 56(2):1900495. Doi: 10.1183/13993003.00495-2019.
Silva PA, Soares SM, Santos JF, Silva LB. Cut-off point for WHOQOL-bref as a measure of quality of life of older adults. Rev Saude Publica 2014; 48(3):390-7. Doi: 10.1590/s0034-8910.2014048004912.
Jo YS, Park S, Kim DK, Yoo CG, Lee CH. The cutoff point of clinical chronic obstructive pulmonary disease questionnaire for more symptomatic patients. BMC Pulm Med 2018; 18(1):38. Doi: 10.1186/s12890-018-0601-0.
Nasiri MJ, Silva DR, Fommasi F et al. Vaccination in post-tuberculosis lung disease management: a review of the evidence. Pulmonology [Preimpresión]. 2023 [consultado 21 nov 2023]. Doi: 10.1016/j.pulmoe.2023.07.002.
Siddiq MAB, Rathore FA, Clegg D, Rasker JJ. Pulmonary Rehabilitation in COVID-19 patients: A scoping review of current practice and its application during the pandemic. Turk J Phys Med Rehabil 2020; 66(4):480-494. Doi: 10.5606/tftrd.2020.6889.
Romero S, Graziani D. Bronquiectasias [Bronchiectasis]. Medicine (Madr) 2018; 12(63):3691-3698. Doi: 10.1016/j.med.2018.09.010.
Kayongo A, Nyiro B, Siddharthan T et al. Mechanisms of lung damage in tuberculosis: implications for chronic obstructive pulmonary disease. Front Cell Infect Microbiol 2023; 13:1146571. Doi: 10.3389/fcimb.2023.1146571.
Sivori M, Almeida M, Benzo R et al. Nuevo consenso argentino de rehabilitación respiratoria: Actualización 2008. Medicina (B. Aires) 2008; 68(4): 325-344.
Byrne A, Allwood B, Schoeman I et al. “Post tuberculosis”: the urgent need for inclusion of lung health outcomes in tuberculosis treatment trials. Eur Respir J 2023; 62: 2300950. Doi: 10.1183/13993003.00950-2023.
Nkereuwem E, Agbla S, Sallahdeen A et al. Reduced lung function and health-related quality of life after treatment for pulmonary tuberculosis in Gambian children: a cross-sectional comparative study. Thorax 2023; 78(3): 281-287. Doi: 10.1136/thorax-2022-219085.
Llanos-Tejada F, Ponce-Chang C. Depresión y adherencia en personas afectadas con tuberculosis. Una exploración preliminar de datos. Rev Neuropsiquiatr 2019; 82(2):104-109. Doi: 10.20453/rnp.v82i2.3536.
Nkereuwem O, Nkereuwem E, Owolabi O et al. Perspectives of TB survivors and policymakers on post-TB disability. Public Health Action 2023; 13(1):17-22. Doi: 10.5588/pha.22.0050.
Walsh KF, Lui JK. Post-tuberculosis pulmonary hypertension: a case of global disparity in health care. Lancet Glob Health 2022;10(4):e476. Doi: 10.1016/S2214-109X(22)00042-0.
Chen Y, Liu C, Lu W et al. Clinical characteristics and risk factors of pulmonary hypertension associated with chronic respiratory diseases: a retrospective study. J Thorac Dis 2016; 8:350–8.
Martinez L, Gray DM, Botha M et al. The Long-Term Impact of Early-Life Tuberculosis Disease on Child Health: A Prospective Birth Cohort Study. Am J Respir Crit Care Med 2023; 207(8):1080-1088. Doi: 10.1164/rccm.202208-1543OC.
Migliori GB, Tiber IS, Zumla A et al; Members of the Global Tuberculosis Network. MDR/XDR-TB management of patients and contacts: Challenges facing the new decade. The 2020 clinical update by the Global Tuberculosis Network. Int J Infect Dis 2020; S1201-9712(20)30045-X.
World Health Organization Regional Office for Europe. The Role of Surgery in the Treatment of Pulmonary TB and Multidrug and Extensively Drug-Resistant TB. Copenhagen, Denmark, 2014. [Internet]. [Consultado 26 feb 2020]. Disponible en: http://www.euro.who.int/__data/assets/pdf_file/0005/259691/The-role-of-surgery-inthe-treatment-of-pulmonary-TB-and-multidrug-and-extensively-drug-resistant-TB.pdf?ua=1.
Nahid P, Mase SR, Migliori GB et al. Treatment of Drug-Resistant Tuberculosis. An Official ATS/CDC/ERS/IDSA Clinical Practice Guideline. Am J Respir Crit Care Med 2019; 200: e93–e142. Doi: 10.1164/rccm.201909-1874ST.
Caminero JA. Guidelines for Clinical and Operational Management of Drug-Resistant Tuberculosis. International Union Against Tuberculosis and Lung Disease, Paris, 2013; pp. 1–232.
Ravimohan S, Kornfeld H, Weissman D, Bisson GP. Tuberculosis and lung damage: from epidemiology to pathophysiology. Eur Respir Rev 2018; 27(147): 170077.
GOLD. Global Strategy for the Diagnosis, Management and Prevention of Chronic Obstructive Pulmonary Disease. 2024. [Internet]. [Consultado 26 feb 2020]. Disponible en: www.goldcopd.org.
Stolz D, Mkorombindo T, Schumann DM et al. Towards the elimination of chronic obstructive pulmonary disease: a Lancet Commission. Lancet 2022;400(10356):921-972. Doi: 10.1016/S0140-6736(22)01273-9.
Gonzalez-Garcia M, Maldonado D, Barrero M, Casas A, Perez-Padilla R, Torres-Duque CA. Arterial blood gases and ventilation at rest by age and sex in an adult Andean population resident at high altitude. Eur J Appl Physiol 2020;120(12):2729-2736. Doi: 10.1007/s00421-020-04498-z.
Pérez Padilla JR, Vázquez García JC. Estimación de los valores gasométricos en diferentes alturas sobre el nivel del mar en México. Rev Invest Clin 2000; 52(2):148-55.