Clinical Manifestations of Post-COVID in Adults in the Republic of Panama
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Abstract
Introduction: individuals who suffer from COVID-19 can either be asymptomatic or have symptoms that can range from mild, moderate to severe. However, a significant amount of the population can present a group of long-term clinical manifestations that have been englobed by the term post-COVID syndrome.
Methodology: we executed an observational and transverse study on patients with a history of SARS-CoV-2 infection, between March 2020- March 2021 in the Republic of Panama. Simple random sampling was utilized on post-COVID clinic patients and the general population with the help of a self-administered digital survey.
Results: the answers of 248 participants were analyzed; 64.5% were female with an average age of 36.7 years. Arterial hypertension (14.5%) and obesity/overweight (18.1%) were the most frequent comorbidities among the studied population. Around 87% were mild and 85.9% suffered from at least one long- term symptom. Risk factors associated with symptom persistence includes the presence of 7 or more symptoms during the acute phase of disease (OR 9.46), as well as the female gender (OR 5.07). Other factors include ventilatory support (OR 2.58) and hypertension (OR 2.46). Acute phase symptoms that persisted long-term include headaches, dyspnea, general malaise and fatigue.
Conclusions: post-COVID syndrome is a public health issue that requires solutions obtained through research and their application within the healthcare system. To our knowledge, this is the first prevalence study concerning post-COVID symptoms executed in the Republic of Panama. It provides current information to the limited knowledge on symptoms that appear after an acute infection of COVID-19.
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References
Hassan SA, Sheikh FN, Jamal S, Ezeh JK, Akhtar A. Coronavirus (COVID-19): A Review of Clinical Features, Diagnosis, and Treatment. Cureus. 2020; 12(3): e7355. Doi: 10.7759/cureus.7355
Revzin MV, Raza S, Warshawsky R et al. Multisystem imaging manifestations of covid-19, part 1: Viral pathogenesis and pulmonary and vascular system complications. Radiographics 2020;40(6):1574–99. Doi: 10.1148/rg.2020200149.
National Institute for Health and Care Excellence (NICE). COVID-19 rapid guideline: managing the long-term effects of COVID-19. London, 2020 [Internet]. [Consultado 23 abril 2022]. Disponible en: https://www.nice.org.uk/guidance/ng188
Crook H, Raza S, Nowell J, Young M, Edison P. Long covid - Mechanisms, risk factors, and management. BMJ 2021;374:n1648. Doi:10.1136/bmj.n1648.
Logue JK, Franko NM, McCulloch DJ et al. Sequelae in Adults at 6 Months after COVID-19 Infection. JAMA Netw Open 2021;4(2): e210830. Doi: 10.1001/jamanetworkopen.2021.0830.
Lopez-Leon S, Wegman-Ostrosky T, Perelman C et al. More than 50 Long-term effects of COVID-19: a systematic review and meta-analysis. [Preprint]. MedRxiv 2021; 21250617. Doi: 10.1101/2021.01.27.21250617
Petersen MS, Kristiansen MF, Hanusson KD et al. Long COVID in the Faroe Islands: A Longitudinal Study Among Nonhospitalized Patients. Clin Infect Dis 2021;73(11):e4058–63. Doi: 10.1093/cid/ciaa1792
Walitt B, Bartrum E. A clinical primer for the expected and potential post-COVID-19 syndromes. Pain Rep 2021;6(1):e887. Doi: 10.1097/PR9.0000000000000887.
Ministerio de Salud de Panamá. COVID-19 2021. [Internet]. [Consultado 23 abril 2022]. Disponible en: https://www.minsa.gob.pa/sites/default/files/publicacion-general/informe_covid19_31_de_marzo_2021_presidencia.pdf
Noriega-Aguirre L, Alvear M, Villarreal O et al. Características clínicas de pacientes con COVID-19 al momento de su ingreso hospitalario en los primeros cinco meses de pandemia en la República de Panamá́. Respirar 2021; 13: 117-126.
Sudre CH, Murray B, Varsavsky T et al. Attributes and predictors of long COVID. Nat Med 2021; 27: 626–631. Doi: 10.1038/s41591-021-01292-y
Huang C, Huang L, Wang Y et al. 6-month consequences of COVID-19 in patients discharged from hospital: a cohort study. The Lancet 2021;397(10270):220–32. Doi: 10.1016/S0140-6736(20)32656-8.
Hossain MA, Hossain KMA, Saunders K et al. Prevalence of Long COVID symptoms in Bangladesh: A prospective Inception Cohort Study of COVID-19 survivors. BMJ Global Health 2021;6(12):e006838. Doi: 10.1136/bmjgh-2021-006838.
Townsend L, Dowds J, O’Brien K et al. Persistent poor health after covid-19 is not associated with respiratory complications or initial disease severity. Ann Am Thorac Soc 2021;18(6):997–1003. Doi: 10.1513/AnnalsATS.202009-1175OC.
Goërtz YMJ, van Herck M, Delbressine JM et al. Persistent symptoms 3 months after a SARS-CoV-2 infection: the post-COVID-19 syndrome? ERJ Open Res 2020;6(4):00542–2020. Doi: 10.1183/23120541.00542-2020.
van den Borst B, Peters JB, Brink M et al. Comprehensive Health Assessment 3 Months after Recovery from Acute Coronavirus Disease 2019 (COVID-19). Clin Infect Dis 2021;73(5):e1089-e1098. Doi: 10.1093/cid/ciaa1750.
Yong SJ. Long COVID or post-COVID-19 syndrome: putative pathophysiology, risk factors, and treatments. Infect Dis (Lond) 2021;53(10):737-754. Doi: 10.1080/23744235.2021.1924397.
Brucki SMD, Corazza LA, de Queiroz AP et al. Neurological complications in COVID-19 patients from Latin America. Brain 2020;144(3):e29. Doi: 10.1093/brain/awaa440.
Wong AW, Shah AS, Johnston JC, Carlsten C, Ryerson CJ. Patient-reported outcome measures after COVID-19: A prospective cohort study. Eur Respir J 2020; 56: 2003276. Doi: 10.1183/13993003.03276-2020
Halpin SJ, McIvor C, Whyatt G et al. Postdischarge symptoms and rehabilitation needs in survivors of COVID-19 infection: A cross-sectional evaluation. J Med Virol 2021;93(2):1013-1022. Doi: 10.1002/jmv.26368.
Tenforde MW, Kim SS, Lindsell CJ et al. Symptom Duration and Risk Factors for Delayed Return to Usual Health Among Outpatients with COVID-19 in a Multistate Health Care Systems Network - United States, March-June 2020. MMWR 2020;69(30):993-998. Doi: 10.15585/mmwr.mm6930e1.