Frequency of Microorganisms in Patients with Acute Respiratory Infections Identified by a Respiratory Panel in a Private Hospital in Panama, 2022-2023
Main Article Content
Abstract
Introduction: Acute respiratory infections represent a global burden for health systems, currently the fourth leading cause of death worldwide. After the SARS-CoV-2 pandemic, it was necessary to study its etiology. The objective is to identify microorganisms associated with acute respiratory infections registered in a private hospital in the country.
Methodology: A descriptive cross-sectional study was conducted by gathering data between January 2022 and June 2023 from the BioFire® FilmArray® Pneumonia panel, where 294 positive samples were selected by non-probabilistic convenience sampling.
Results: Among the samples analyzed, 58.5% were from male individuals, with a mid-range of 48 years. The age groups with the highest frequency were < 5 years 39.1% and > 60 years 20.7%. Most samples were taken by nasopharyngeal swab 78.9%. The most identified microorganisms were human rhinovirus/enterovirus detected in 30.6%, followed by parainfluenza 12.6%, adenovirus 12.3%, respiratory syncytial virus 10.9%, SARS-CoV-2 10.5% and influenza A 10.2%.
Conclusion: Most of the infections occurred at the extremes of age, which suggests the vulnerability of these groups and the need for hospital care. The study’s results emphasize the importance of preventive measures to reduce the transmission of respiratory infections.
Downloads
Article Details
This work is licensed under a Creative Commons Attribution 4.0 International License.
References
Troeger C, Blacker B, Khalil IA et al. Estimates of the global, regional, and national morbidity, mortality, and aetiologies of lower respiratory infections in 195 countries, 1990–2016: a systematic analysis for the Global Burden of Disease Study 2016. Lancet Infect Dis 2018;18(11):1191–210. Doi: 10.1016/S1473-3099(18)30310-4
Núñez-Samudio V, Landires I. Epidemiology of viral respiratory infections in a pediatric reference hospital in Central Panama. BMC Infect Dis 2021;21(1):43. Doi: 10.1186/s12879-020-05720-1
Wang X, Li Y, O’Brien KL et al. Global burden of respiratory infections associated with seasonal influenza in children under 5 years in 2018: a systematic review and modelling study. Lancet Glob Health 2020;8(4):e497–510.
Moriyama M, Hugentobler WJ, Iwasaki A. Seasonality of Respiratory Viral Infections. Annu Rev Virol 2020;7(1):83–101. Doi: 10.1146/annurev-virology-012420-022445
Zhu N, Zhang D, Wang W et al. A Novel Coronavirus from Patients with Pneumonia in China, 2019. N Engl J Med 2020;382(8):727–33. Doi: 10.1056/NEJMoa2001017
Lai CC, Wang CY, Wang YH, Hsueh SC, Ko WC, Hsueh PR. Global epidemiology of coronavirus disease 2019 (COVID-19): disease incidence, daily cumulative index, mortality, and their association with country healthcare resources and economic status. Int J Antimicrob Agents 2020;55(4):105946. Doi: 10.1016/j.ijantimicag.2020.105946
Brueggemann AB, Jansen van Rensburg MJ, Shaw D et al. Changes in the incidence of invasive disease due to Streptococcus pneumoniae, Haemophilus influenzae, and Neisseria meningitidis during the COVID-19 pandemic in 26 countries and territories in the Invasive Respiratory Infection Surveillance Initiative: a prospective analysis of surveillance data. Lancet Digit Health 2021;3(6):e360–70. Doi: 10.1016/S2589-7500(21)00077-7
bioMérieux. The BioFire® FilmArray® Pneumonia (PN) Panel Syndromic infectious disease testing for Pneumonia. 2018 [Internet]. [Consultado 2 jul 2024] Disponible en: https://www.biofiredx.com/products/the-filmarray-panels/filmarray-pneumonia/
Gorse GJ, Donovan MM, Patel GB, Balasubramanian S, Lusk RH. Coronavirus and Other Respiratory Illnesses Comparing Older with Young Adults. Am J Med 2015;128(11):1251.e11-1251.e20. Doi: 10.1016/j.amjmed.2015.05.034
Castañeda-Ribeyro A, Martins-Luna J, Verne E et al. High prevalence and clinical characteristics of respiratory infection by human rhinovirus in children from Lima-Peru during years 2009–2010. PLoS One 2022;17(7):e0271044. Doi: 10.1371/journal.pone.0271044
Brealey JC, Sly PD, Young PR, Chappell KJ. Viral bacterial co-infection of the respiratory tract during early childhood. FEMS Microbiol Lett 2015;362(10). Doi: 10.1093/femsle/fnv062
González-Granado LI, Martín-Nalda A, Alsina L, Neth O, Santamaría M, Soler-Palacín P. Respiratory syncytial virus infections requiring hospitalization in patients with primary immunodeficiency. An Pediatr (Engl Ed) 2022;96(6):492–500. Doi: 10.1016/j.anpede.2022.03.002
Talbot HK, Belongia EA, Walsh EE, Schaffner W. Respiratory Syncytial Virus in Older Adults. Infect Dis Clin Pract 2016;24(6):295–302. Doi: 10.1097/IPC.0000000000000455
Nguyen-Van-Tam JS, O’Leary M, Martin ET et al. Burden of respiratory syncytial virus infection in older and high-risk adults: a systematic review and meta-analysis of the evidence from developed countries. Eur Resp Rev 2022;31(166):220105. Doi: 10.1183/16000617.0105-2022
Karami H, Sadeghi K, Zadheidar S et al. Surveillance of endemic coronaviruses during the COVID‐19 pandemic in Iran, 2021–2022. Influenza Other Respir Viruses. 2023;17(3). Doi: 10.1111/irv.13128
Hadj Hassine I. Covid‐19 vaccines and variants of concern: A review. Rev Med Virol 2022;32(4). Doi: 10.1183/13993003.00735-2022
FDA. FDA Approves First Respiratory Syncytial Virus (RSV) Vaccine. 2023 [Internet].[Consultado 2 jul 2024]. Disponible en: https://www.fda.gov/news-events/press-announcements/fda-approves-first-respiratory-syncytial-virus-rsv-vaccine#:~:text=Today%2C%20the%20U.S.%20Food%20and,years%20of%20age%20and%20older.
Feldman RG, Antonelli-Incalzi R, Steenackers K et al. Respiratory Syncytial Virus Prefusion F Protein Vaccine Is Efficacious in Older Adults With Underlying Medical Conditions. Clin Infect Dis 2024;78(1):202–9. Doi: 10.1093/cid/ciad471.
Vygen-Bonnet S, Hellenbrand W, Garbe E et al. Safety and effectiveness of acellular pertussis vaccination during pregnancy: a systematic review. BMC Infect Dis 2020;20(1):136. Doi: 10.1186/s12879-020-4824-3.
PAHO. Situación de Influenza, SARS CoV-2, VRS y otros virus respiratorios - Región de las Américas. Sección Panamá [Internet]. [Consultado 2 jul 2024]. Disponible en: https://www.paho.org/es/informe-situacion-influenza
Martin-Loeches I, Torres A, Nagavci B et al. ERS/ESICM/ESCMID/ALAT guidelines for the management of severe community-acquired pneumonia. Eur Resp J 2023;61(4):2200735. Doi: 10.1183/13993003.00735-2022.