Bilateral Bronchial Stenosis Secondary to Invasive Fungal Tracheobronchitis Caused by Penicillium Chrysogenum in an Immunocompetent Patient. Clinical Case Presentation

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Byron L. Saraguro-Ramirez
https://orcid.org/0000-0003-4271-3909
Fernanda López-Merino
https://orcid.org/0009-0001-2585-8754
Byron L. Jaramillo-Samaniego
Denisse A. Menéndez-Castello
https://orcid.org/0000-0003-4022-9988

Abstract

Introduction: Invasive fungal tracheobronchitis caused by Penicillium chrysogenum is a rare opportunistic mycosis in immunocompromised patients, with extremely limited reports in immunocompetent patients. It involves a diagnostic challenge due to its low suspicion, low prevalence, and nonspecific clinical findings. 


Clinical case: A 61-year-old male, with no history of immunosuppressive diseases, with severe dyspnea secondary to bilateral bronchial stenosis, determined by chest CT scan and resolved using various bronchoscopic techniques. Microbiological and pathological studies indicated the diagnosis of invasive fungal tracheobronchitis. 


Conclusion: Respiratory fungal infections are rare diseases associated with a high mortality rate. Molecular diagnosis allows for accurate and timely diagnosis, reducing morbidity and mortality rates. 

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How to Cite

Bilateral Bronchial Stenosis Secondary to Invasive Fungal Tracheobronchitis Caused by Penicillium Chrysogenum in an Immunocompetent Patient. Clinical Case Presentation. (2026). Respirar, 18(2). https://doi.org/10.55720/

References

Kaur T, Agarwal R, Yee P, Shah A, Lydon E. Fungal lung disease. Eur Respir J 2024;64:2400803. https://doi.org/10.1183/13993003.00803-2024

De la Fuente A, Astorga F, Arancibia F, Gutiérrez R, Andino P. Infecciones fúngicas respiratorias: experiencia del Instituto Nacional del Tórax, Santiago de Chile. Respirar 2021;13:55-63.

Shi X, Ye J, Liu P, Gao W, Feng Z. Case report: Rare pulmonary fungal infection caused by Penicillium digitatum: the first clinical report in China. Front Med 2024;11:1424586. https://doi.org/10.3389/fmed.2024.1424586

Lin Ch, Lun W, Chang Ch, Chang H, Chung H. Invasive fungal tracheobronchitis in mechanically ventilated critically ill patients: underlying conditions, diagnosis, and outcomes. Ann Intensive Care 2017;7:9. https://doi.org/10.1186/s13613-016-0230-9

Oshikata Ch, Watanabe M, Saito A, Yasueda H, Akiyama K. Allergic bronchopulmonary mycosis caused by Penicillium luteum. Med Mycol Case Rep 2017;15:9-11. https://doi.org/10.1016/j.mmcr.2016.11.007

Bajaj I, Veiga T, van Diesel D, Pronk J, Daran J. Functional characterization of a Penicillium chrysogenum mutanase gene induced upon co-cultivation with Bacillus subtilis. BMC Microbiology 2014;14:114. https://doi.org/10.1186/1471-2180-14-114

Shaaban R, Elnaggar M, Khalil N, Nasser A. A comprehensive review on the medicinally valuable endosymbiotic fungi Penicillium chrysogenum. Arch Microbiol 2023;205:240. https://doi.org/10.1007/s00203-023-03580-2

Geltner C, Lass C, Bonatti H, Muller L, Stelzmuller I. Invasive Pulmonary Mycosis Due to Penicillium chrysogenum: a New Invasive Pathogen. Transplantation 2013;95(4). https://doi.org/10.1097/TP.0b013e31827ff214

D’ Antonio D, Violante B, Farina C, Sacco R, Angelucci D. Necrotizing Pneumonia Caused by Penicillium chrysogenum. J Clin Microbiol 1997;35(12):3335-7.. https://doi.org/10.1128/jcm.35.12.3335-3337.1997

Ríos G, Barillas S, Castillo J, Soto A, Choc M. Acute respiratory failure with fatal outcome due to Penicillium chrysogenum in a man from Guatemala with a seminoma (germ cell tumor). Chest 2021;160(4):A307-A308. https://doi.org/10.1016/j.chest.2021.07.313

Ramírez I, Hidrón A, Cardona R. Successful treatment of pulmonary invasive fungal infection by Penicillium non-marneffei in a lymphoblastic lymphoma: case report and literature review. Clin Case Rep 2018;6(6):1153-1157. https://doi.org/10.1002/ccr3.1527

Randhawa P, Nouraei R, Howard D, Sandhu G, Petrou M. Penicillium species as a rare isolate in tracheal granulation tissue: a case series. J Med Case Rep 2008;2:84. https://doi.org/10.1186/1752-1947-2-84

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